background


Early Enteral Nutrition in Acutely Ill Patients: A Systematic Review

 

Paul E. Marik, Gary P. Zaloga

 

 

Crit Care Med 2001 Vol. 29, No. 12

 

 

Objective: to evaluate the effect of early enteral nutrition on the outcome of critically ill and injured patients.

Data Sources: MEDLINE, citation review of relevant primary and review articles, personal files, and contact with expert informants.

Study Selection: randomized, controlled studies that compared early with delayed enteral nutrition in hospitalized adult postoperative, trauma, head-injured, burn, or medical intensive care unit (ICU) patients. From 161 articles screened, 27 were identified as randomized, controlled trials comparing early with delayed enteral nutrition and were included for data extraction. Of these, 12 were excluded. None of the studies included medical ICU patients.

Data Extraction: fifteen studies containing 753 subjects were analyzed. Descriptive and outcome data were extracted independently from the articles by the two reviewers. Main outcome measures were infections, non infectious complications, length of hospital stay, and mortality. The meta-analysis was performed using the random effects model.

Data Synthesis: early enteral nutrition was associated with a significantly lower incidence of infections (relative risk reduction, 0.45; 95% confidence interval, 0.30–0.66; p = .00006; test for heterogeneity, p = .049) and a reduced length of hospital stay (mean reduction of 2.2 days; 95% confidence interval, 0.81–3.63 days; p = .004; test for heterogeneity, p = .0012). There were no significant differences in mortality or non infectious complications between the two groups of patients.

Conclusions: the results of this meta-analysis support the experimental data demonstrating the benefit of the early initiation of enteral nutrition. The results of this meta-analysis must, however, be interpreted with some caution because of the significant heterogeneity between studies.

 

Fulltext

formazione_strumenti_flowchart-linee guida

Un reparto di Terapia Intensiva è un unico organismo… Non si può curare gli ammalati senza prendersi cura anche degli operatori.

Link veloci

Gestire il dolore

ico-flowchartdoloreFlowchart dolore
ico-vnrVNR
ico-bpsBPS

Gestire la sedazione

ico-flowchart-sedaz-agitFlowchart sedaz/agitaz
ico-rassRASS

Gestire il delirium

ico-flowchart-deliriumFlowchart Delirium
ico-manuale-cam-icuManuale CAM-ICU
ico-schedalavoro-cam-icuScheda di lavoro CAM-ICU
ico-icdscICDSC

 

Questo sito è stato realizzato grazie al contributo di:

regionelombardia

Finanziamento per la Ricerca Indipendente
(Decreto DGS 13456 del 22 dicembre 2010)


Design by Pixelsparadise